解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Urinary metabolites of scutellarin, the main effective constituent of breviscapine, a cerebrovascular and cardiovascular drug consisting of total flavonoids of Erigeron breviscapus, were investigated in rats. Two major metabolites were isolated from the urine of rats following oral administration of scutellarin and id...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2007-967128
更新日期:2007-04-01 00:00:00
abstract::A contribution of the volatile oil from ginger rhizomes (Zingiber officinale Roscoe) on inhabiting the 5-HT3 receptor complex had been shown. In the present study a possible interaction of some compounds of the volatile oil with the 5-HT3 receptor system expressed in N1E-115 cells and with the serotoninergic system of...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2007-967171
更新日期:2007-04-01 00:00:00
abstract::Human vascular endothelial cells (HUVECs) were exposed to CoCl2 as an in vitro model of hypoxia. Expression of VCAM-1 (vascular cell adhesion molecule), reduction of PECAM-1 (platelet endothelial cell adhesion molecule) and cytoskeletal changes without alterations in cell viability were observed. HUVECs were also expo...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2007-967118
更新日期:2007-03-01 00:00:00
abstract::Products derived from Noni fruit (Morinda citrifolia) have been commercialised in the USA since the 1990s and are increasingly distributed all over the world. A large number of beneficial effects have been claimed for Noni. Fruit juice of Noni has been approved as a Novel Food by the European Commission in 2003. This ...
journal_title:Planta medica
pub_type: 杂志文章,评审
doi:10.1055/s-2007-967115
更新日期:2007-03-01 00:00:00
abstract::We describe in this paper that the alkaloid 4-methylaaptamine, isolated from the marine sponge Aaptos aaptos, inhibited HSV-1 infection. We initially observed that 4-methylaaptamine inhibited HSV-1 replication in Vero cells in a dose-dependent manner with an EC50 value of 2.4 microM. Moreover, the concentration requir...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2007-967109
更新日期:2007-03-01 00:00:00
abstract::The quantification of free and total alkannins in 13 endemic Anatolian Alkanna species is described for the first time. Extraction of the samples was performed by sonication with hexane, followed by hydrolysis in 1 N NaOH. For analysis, a new HPLC method, utilizing reversed phase material (Synergi Max RP), was develop...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2007-967110
更新日期:2007-03-01 00:00:00
abstract::The inhibitory effects of selected phenolic lichen substances were tested against a panel of methicillin- and multidrug-resistant Staphylococcus aureus. Depsidones with long alkyl chains on both of the aromatic rings were consistently active against the strains tested, comparable to or better than the level of clinica...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-957070
更新日期:2007-02-01 00:00:00
abstract::Two new phenolic glycosides characterized as idesin salicylate (1) and 2-hydroxyphenol-1-O-beta-D-glucopyranosyl-(6-->1)- alpha-L-rhamnopyranoside (2) were isolated with four known compounds, idescarpin (3), idesin (4), 1-hydroxy-6-oxocyclohex-2-enecarboxylic acid methyl ester (5) and salirepin (6), from the fruits of...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-951771
更新日期:2007-02-01 00:00:00
abstract::The aim of this study was to investigate the anti-asthmatic effects of Perilla seed oil in vitro and in vivo in sensitized guinea pigs. Aerosolized antigen caused an immediate bronchoconstriction. Perilla seed oil per os inhibited the increase in lung resistance and the decrease in dynamic lung compliance in a dose-de...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-957062
更新日期:2007-01-01 00:00:00
abstract::The evidence for loss of Ca2+ homeostasis due to neuronal degeneration is considerable and rapidly increasing. In this study, we try to evaluate the protective effect of tetrandrine (TET), an alkaloid isolated from the Chinese medicinal herb Radix Stephania tetrandrae S., on amyloid-beta protein (Abeta) and 1-methyl-4...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-951690
更新日期:2006-11-01 00:00:00
abstract::We investigated the apoptotic effects of the protopanaxadiol ginsenosides, Rb (1) and Rb (2), and their intestinal bacterial metabolite, 20-O-beta-D-glucopyranosyl-20(S)-protopanaxadiol (M1), and of the protopanaxatriol ginsenoside, Rg (1), and its intestinal bacterial metabolite, 20(S)-protopanaxatriol, in activated ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-947223
更新日期:2006-10-01 00:00:00
abstract::VERATRUM CALIFORNICUM (Liliaceae) is an important monocotyledonous medicinal plant which is the only source of the anticancer compound cyclopamine. An IN VITRO culture system for somatic embryogenesis and green plant regeneration of VERATRUM CALIFORNICUM was developed. Embryogenic calli were induced from mature embryo...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-946697
更新日期:2006-10-01 00:00:00
abstract::Amphotericin B (AmB) is a representative antibiotic for the control of serious fungal infections, and its fungicidal activity was greatly enhanced by allicin, an allyl-sulfur compound from garlic. In addition to the plasma membrane permeability change, AmB induced vacuole membrane damage so that the organelles were vi...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-947203
更新日期:2006-10-01 00:00:00
abstract::Genome sequencing provides new opportunities and challenges for identifying genes for the biosynthesis of secondary metabolites. A putative biosynthetic gene cluster of fumigaclavine C, an ergot alkaloid of the clavine type, was identified in the genome sequence of ASPERGILLUS FUMIGATUS by a bioinformatic approach. Th...
journal_title:Planta medica
pub_type: 杂志文章,评审
doi:10.1055/s-2006-947195
更新日期:2006-10-01 00:00:00
abstract::The specific physiological responses induced by inhaling R-(-)- as well as S-(+)-linalool in 24 human subjects undergoing experimental stress were investigated in this study. Various physiological parameters of the autonomous nervous system (heart rate, blood pressure, electrodermal activity) as well as the endocrine ...
journal_title:Planta medica
pub_type: 杂志文章,随机对照试验
doi:10.1055/s-2006-947202
更新日期:2006-10-01 00:00:00
abstract::Teak ( Tectona grandis L.f., Verbenaceae) sawdust extract inhibited the growth of Aspergillus niger. Centrifugal partition chromatography was used to isolate the active compounds. By (1)H-NMR the active compounds were identified as deoxylapachol and tectoquinone. Two A. niger transgenic strains which show induction of...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-946676
更新日期:2006-08-01 00:00:00
abstract::In Brazil, Plectranthus species are known as "boldo" and have been used in popular medicine for analgesic and dyspeptic purposes. Plectranthus need to be well identified in order to be used as commercially genuine medicinal plants. Here we describe AFLP DNA patterns able to distinguish among different Pectranthus spec...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-946673
更新日期:2006-08-01 00:00:00
abstract::Extracts from Pygeum africanum, Serenoa repens and Cucurbita pepo are used in the treatment of benign prostatic hyperplasia (BPH) and prostate cancer (PCa). The activity of the androgen receptor (AR) is known to control growth of the prostate. Here, we examined extracts of these plants for their antiandrogenic activit...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-946638
更新日期:2006-07-01 00:00:00
abstract::From the fresh rhizomes of Tamus communis five phenanthrenes (1 - 5) were isolated under the guidance of cytotoxic assays in HeLa cells. The compounds were obtained from the highly active CHCl (3) fraction of the MeOH extract by using multistep chromatographic purifications, including VLC, preparative TLC, HPLC and ge...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-941505
更新日期:2006-06-01 00:00:00
abstract::Overexpression of the protein transporter P-glycoprotein (Pgp, MDR1) at the cell surface is a major cause of multidrug resistance (MDR) and poor response to treatment in cancer chemotherapy and therapy for leishmaniasis. The present study shows that conferone, a sesquiterpene coumarin ether isolated for the first time...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-931574
更新日期:2006-06-01 00:00:00
abstract::The natural compound tyropeptin A, a new peptidyl aldehyde proteasome inhibitor, was tested for its trypanocidal activity in vitro using culture-adapted bloodstream forms of Trypanosoma brucei. The concentrations of tyropeptin A required to reduce the growth rate by 50 % and to kill all cells were 10 and 100 times low...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-931600
更新日期:2006-06-01 00:00:00
abstract::During the screening of antimalarial substances, the 80% EtOH extract from the outer bark of Ochna integerrima Merr. (Ochnaceae) was shown to have a good anti-malarial activity (IC50 value: 6.5 microg/mL) whereas extracts from the inner barks of O.integerrima showed no antimalarial activity. Biflavanone (1), which had...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-931569
更新日期:2006-06-01 00:00:00
abstract::The pharmacokinetics of huperzine A in dogs after single intravenous and oral administrations was investigated. Concentrations of huperzine A were determined by a validated liquid chromatography-tandem mass spectrometry (LC-MS/MS) method. Pharmacokinetic parameters were calculated by non-compartmental methods. After s...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-931566
更新日期:2006-05-01 00:00:00
abstract::Reduced estrogen levels occurring during menopause in woman are accompanied by a variety of disorders, e. g., hot flushes, depressions, osteoporosis, increase of body weight, and reduced movement drive. In this study we investigated the combined effects of physical activity, estradiol substitution, and a phytoestrogen...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-931579
更新日期:2006-05-01 00:00:00
abstract::Two indole alkaloids were isolated from the culture of Aspergillus fumigatus (strain No. CY018), an endophytic fungus harboring inside the elder leaf of Cynodon dactylon. These two chemicals were identified as fumigaclavine C and fumitremorgin C. In screening the bioactivity of these two indole alkaloids, their vasore...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2005-916235
更新日期:2006-04-01 00:00:00
abstract::Phytochemical investigations of the stem of Kadsura heteroclita (Roxb) Craib (Schizandraceae) resulted in the isolation and structure elucidation of six new triterpenoidal compounds named heteroclitalactones A-E (1-5) as well as heteroclic acid (6) and heteroclitalactone F (7), which was isolated for the first time fr...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2005-916263
更新日期:2006-04-01 00:00:00
abstract::Three new dammar-type triterpenoid caffeates (1-3) were isolated from the stalks of Celastrus rosthornianus Loes. Their structures were established through various spectral studies as 3beta,20(S),24(S)-trihydroxyldammar-25-ene 3-caffeate (1), 3beta,20(S),24(R)-trihydroxyldammar-25-ene 3-caffeate (2) and 3beta,20(S),25...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2005-916214
更新日期:2006-03-01 00:00:00
abstract::The effects of phytoestrogens on the female breast are discussed controversially. On the one hand, epidemiological and experimental data provide evidence that dietary phytoestrogens may prevent the development of breast cancer. On the other hand, in breast cancer cell lines and tumour models isoflavone phytoestrogens ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2005-916229
更新日期:2006-03-01 00:00:00
abstract::Two new C(18) dibenzocyclooctadiene lignans named heteroclitalignans A and B (1 and 3), one new C(19) homolignan named heteroclitalignan C(4) and one new natural product named heteroclitalignan D(2), together with the four known lignans kadsurarin (5), kadsulignan E (6), d-epigalbacin, and meso-dihydroguaiaretic acid ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2005-916213
更新日期:2006-02-01 00:00:00
abstract::Echinacea purpurea cell cultures have been established for the production of secondary and possibly bioactive compounds using elicitation techniques. Different elicitors including yeast elicitor, methyl jasmonate, glutathione, and manganese ions were used and compared for their effects on the formation of phenolics in...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2005-873201
更新日期:2006-02-01 00:00:00
abstract::Eleven sesquiterpenoids have been isolated from the whole plants of Youngia japonica (Asteraceae). Among these sesquiterpenoids, five were identified as new compounds on the basis of spectroscopic methods and chemical analysis. Their structures were 3-oxo-8alpha-(4-hydoxyphenyl)acetoxy-10(14),11(13)-guaiadien-12,6-oli...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2005-916182
更新日期:2006-02-01 00:00:00
abstract::Six diarylheptanoids were isolated from the rhizome of Alpinia officinarum (Zingiberaceae) as inhibitors of nitric oxide (NO) production in the lipopolysaccharide-activated macrophage cell line RAW 264.7. A double bond at C-4 of the linker between two aromatic rings was found to be essential for activity. Furthermore,...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2005-873176
更新日期:2006-01-01 00:00:00
abstract::A cell-based method for screening drug candidates from herbal extracts that have possible anti-type II diabetic effects was established. The differentiation of preadipocytes into adipocytes was used as a sensitive primary indicator of a drug's potential effect on type II diabetes. We established a quantitative method ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2005-916215
更新日期:2006-01-01 00:00:00
abstract::Ten clones of dark-leaved willows ( Salix myrsinifolia Salisb.) were grown for two years on two different sites, Luikonlahti and Punkaharju, using various combinations of soil cultivation, fertilization and mulch treatments, with the objective of comparing the effect of different cultivation methods on the growth and ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2005-873138
更新日期:2005-12-01 00:00:00
abstract::In addition to 7-methoxy-2-methyl-3,4,5-trihydroxyanthraquinone (1), physcion (2), macrosporin (3), deoxybostrycin (4), altersolanol B (5) and dactylariol (6), a new hexahydroanthraquinone named pleospdione (7) was isolated from the culture of Pleospora sp . IFB-E006, an endophytic fungus residing in the normal stem o...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2005-864190
更新日期:2005-11-01 00:00:00
abstract::Some diterpenoids show various biological activities, including anti-inflammatory, anti-HIV and anti-tumor activity. Previously, we have focused our research on the apoptosis-inducing properties of diterpenoids and found that some ent-kaurene-type diterpenoids induced apoptosis in human leukemia HL-60 cells. In this s...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2005-873133
更新日期:2005-11-01 00:00:00
abstract::The chloroform extract of Valeriana officinalis led to the isolation of clionasterol-3-O-beta-D-glucopyranoside and a mixture of 6'-O-acyl-beta-D-glucosyl-clionasterols. The acyl moieties were identified as hexadecanoyl, 8 E,11 E-octadecadienoyl and 14-methylpentadecanoyl by alkaline hydrolysis followed by GC-MS analy...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2005-864179
更新日期:2005-10-01 00:00:00
abstract::We have previously shown that 11 ent-kauranes isolated from the stems of Annona squamosa exhibited immunomodulating effects in leukocytes. In this study, a cellular model using isolated human neutrophils, which are important in the pathogenesis of rheumatoid arthritis, ischemia-reperfusion injury, chronic obstructive ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2005-871234
更新日期:2005-10-01 00:00:00
abstract::Four new benzofurans trans-5-(3-hydroxypropyl)-7-methoxy-2-[2,3-dihydro-3-hydroxymethyl-7-methoxy-2-(3-methoxy-4-hydroxyphenyl)-benzofuran-5-yl]benzofuran (1), (E)-5-(2-formylvinyl)-7-methoxy-2-(3,4-methylenedioxyphenyl)benzofuran (2), 5-(3-butanoyloxypropyl)-7-methoxy-2-(3,4-methylenedioxyphenyl)benzofuran (3), and 5...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2005-871226
更新日期:2005-09-01 00:00:00
abstract::Enzymatic thrombin activity is significantly inhibited only by a few selected natural phenolic compounds (myricetin, rosmarinic acid, caffeic acid phenethyl ester) but more strongly by unsaturated fatty acids like erucic acid and oleic acids. Compared to the inhibitory potential against neutrophil elastase, thrombin a...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2005-871253
更新日期:2005-08-01 00:00:00